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酒石酸銻鉀为广泛沿用的血吸虫病防治药物,我国药典和其他各国药典均有收载,唯含量测定尚存在一些問題,不易掌握。中国药典方法系采用氧化还原方法,在碳酸氢鈉存在下直接以碘溶液进行滴定。但因酒石酸銻鉀在硷性溶液中極不稳定,生成氢氧化銻,进而成为氧化物白色沉淀。因而在滴定过程中氧化物与碘酸緩緩作用,使終点不明确,同时反应不能定量完成,往往不易得到正确的数据。美国药典,英国药典方法与中国药典方法相同。苏联药典方法系采用溴酸鉀溶液氧化破坏指示剂甲紅使其紅色消失作用
Potassium bismuth tartrate is widely used as a schistosomiasis control drug. It is included in the Pharmacopoeia of the People’s Republic of China and other countries’ Pharmacopoeia. However, there are still some problems in content determination and it is not easy to grasp. The Chinese Pharmacopoeia method uses an oxidation-reduction method to titrate directly with an iodine solution in the presence of sodium bicarbonate. However, potassium strontium tartrate is extremely unstable in the ruthenium solution and forms barium hydroxide, which in turn forms an oxide white precipitate. Therefore, during the titration process, oxides and iodic acid slowly act to make the end point unclear. At the same time, the reaction cannot be completed quantitatively, and it is often difficult to obtain correct data. The United States Pharmacopoeia and British Pharmacopoeia methods are identical to the Chinese Pharmacopoeia method. The Soviet Pharmacopoeia method uses potassium bromate solution to oxidize and destroy the indicator red to make its red disappear