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制剂中生物碱的含量測定,各国药典經典方法均采用有机溶剂提取,分离杂貭后再测定含量。近几年来,采用离子交换法分离制剂中生物碱的方法已有不少报导。由于离子交換剂能够比較簡单的定量交換生物碱,并可以用一定溶剂洗脫,这样可以避免一般較复杂费时的提取手續,因而采用离子交换法分离生物碱具有一定的优点。Kamp等报告了用IMAC-22強酸树脂,从顛茄、番木鱉等数种生药及其制剂中分离生物碱,对于用交換柱操作方法、洗脫条件等都进行一定工作。Brochmann-Hanssen連續报导了快速分离测
The contents of alkaloids in the preparations were determined by using the organic solvents in the classic methods of the national pharmacopoeia. In recent years, there have been many reports of methods for separating alkaloids from preparations using ion exchange. Since the ion exchanger can relatively easily quantitatively exchange alkaloids and can be eluted with a certain solvent, this can avoid the generally more complicated and time-consuming extraction procedure, and thus the use of ion exchange to separate alkaloids has certain advantages. Kamp et al. reported the use of IMAC-22 strong acid resin for the separation of alkaloids from several crude drugs such as belladonna and hibiscus and their preparations, and carried out certain work on exchange column operation methods and elution conditions. Brochmann-Hanssen reports a rapid separation test