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目的回顾性分析我院肿瘤患者感染白色念珠菌的发病情况,就其感染的特点及危险因素进行分析研究,探讨防治对策,为合理应用抗菌药物提供参考.方法采用回顾性分析方法,分析2011年6月至2012年6月在我院感染白色念珠菌肿瘤患者68例,对被调查的病历逐一查阅,按年龄、住院天数、感染部位、是否留管及各种侵袭性诊疗操作、免疫抑制剂应用、基础疾病、住院时间长短、是否联合使用抗生素,用药时间及营养状态等作分类登记,并进行总结和分析.结果感染部位分别为口腔20例(29.4%),肺部15例(22.1%),泌尿系8例(11.7%),肠道感染10例(14.7%),真菌血症3例(4.4%),有7例同时存在2个部位感染(10.3%),有5例同时存在3个部位感染(7.3%).单因素分析结果显示,除年龄(χ2=0.06, P=1.00>0.05,)无统计学意义外,住院时间长短、糖皮质激素的应用、是否联合使用抗生素,用药时间、营养状态、是否留管及各种侵入性诊疗操作等均为感染相关危险因素,有统计学意义(P值均小于0.05).给予抗真菌治疗后,62例治愈,6例死亡,死亡率8.8%.结论住院时间长短、糖皮质激素的应用、是否联合使用抗生素,用药时间、营养状态、是否留管及各种侵入性诊疗操作等均为肿瘤患者感染白色念珠菌相关危险因素,减少相关危险因素及易感因素是降低肿瘤患者感染白色念珠菌的有效措施.“,”Objectives To analysis the relative risks factors and formulate the prevention and countermeasure in malignant tumor patients with Candida albicans infection in our hospital. Methods 68 cases of the clinical materials in malignant tumor patients with Candida albicans infection from June 2011 to June 2012 in our hospital were retrospectively analyzed. Results The distribution body parts in malignant tumor patients with Candida albicans infection in our hospital include the mouth (29.4%), lung (22.1%), urinary tract (11.7%), gastroenteritis (14.7%), and fungemia (4.4%). Seven cases have two cites (10.3%) and five cases three cites (7.3%). The total mortality is 8.8% and cure rate 91.2%.The time of hospitalization, applying hormone, using of antibiotics, the state of malnutrition, al sorts of operation and therapy for malignant tumor patients are al the relative risks factors in malignant tumor patients with Candida albicans infection except for age (p<0.05).Conclusions Mostly cancer patients treated with al sorts of operation, radiotherapy, chemotherapy, and long time hospitalization, malnutrition have decline resistibility in body. Using of a large amount of antibiotics cause the microorganism disorder in patient body, and leads to opportunity infection.We must emphasize Candida albicans infection management,control the predisposing factors effectively,and reduce the occurrence of Candida albicans infection.