论文部分内容阅读
目的探讨汉族与维吾尔族血尿酸水平与心血管病相关指标之间的关系。方法对2006年1~12月收集的498名不同民族居民血样本进行尿酸及其他生化指标检测,采用SPSS软件进行方差分析、χ2检验。结果随着血尿酸(SUA)水平的升高,汉族和维吾尔族除了高密度脂蛋白(HDL-C)降低,其他指标均有升高的趋势,统计学检验除血糖(FBS)外其他指标差异均有统计学意义(P<0.05)。相关分析发现,汉族血尿酸与FBS无相关,与HDL-C呈负相关(r=10.271,P<0.01),与其他生理、生化指标均呈正相关;而维吾尔族血尿酸与FBS和HDL-C无关外,其他生理、生化指标均呈正相关。汉族和维吾尔族肥胖、高血压、高血糖、高甘油三酯血症、高胆固醇血症、混合型高脂血症和低高密度脂蛋白血症的检出率均随着SUA水平的增高而升高,统计学检验汉族不同尿酸组之间肥胖、高血压、高甘油三酯血症、代谢综合征检出率差异有统计学意义(P<0.05)。维吾尔族除了高血糖的检出率各尿酸组之间差异无统计学意义(P>0.05)外,其他指标各尿酸水平组代谢性疾病检出率差异均有统计学意义(P<0.05)。结论汉族和维吾尔族血尿酸水平与除血糖外的心血管病相关指标密切相关,并且对各代谢紊乱的发生起促进作用。因此,预防和治疗高尿酸血症对减少心血管病发生和发展将有积极作用。
Objective To investigate the relationship between serum uric acid level and related cardiovascular disease in Han and Uygur nationality. Methods A total of 498 blood samples from different ethnic groups collected from January to December in 2006 were tested for uric acid and other biochemical parameters. ANOVA and χ2 test were performed using SPSS software. Results With the increase of serum uric acid (SUA), Han and Uygur people had higher HDL-C than other indicators, and the other indicators except FBS were statistically different All were statistically significant (P <0.05). Correlation analysis showed that serum uric acid was unrelated to FBS and negatively correlated with HDL-C (r = 10.271, P <0.01), and positively correlated with other physiological and biochemical indexes. However, Uric acid was associated with FBS and HDL-C Irrelevant, other physiological, biochemical indicators were positively correlated. The prevalence of obesity, hypertension, hyperglycemia, hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia and low-density lipoproteinemia in both Han and Uygur nationals increased with the increase of SUA level Statistical analysis showed that the detection rates of obesity, hypertension, hypertriglyceridemia and metabolic syndrome were significantly different between Han Chinese patients with different uric acid (P <0.05). Uygur in addition to the detection rate of high blood sugar among the uric acid group was no significant difference (P> 0.05), the other indicators of uric acid levels of metabolic disease detection rate differences were statistically significant (P <0.05). Conclusions The level of serum uric acid in Han and Uygur nationals is closely related to the cardiovascular disease-related index except blood sugar, and promotes the occurrence of various metabolic disorders. Therefore, the prevention and treatment of hyperuricemia will play a positive role in reducing the occurrence and development of cardiovascular diseases.