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目的:检测食管鳞状细胞癌(Esophageal squamous cell carcinoma ESCC)组织整合素αv(integrinαv ITGA V)的表达,分析ITGA V表达与临床病理因素之间的相关性,探讨ITGA V在ESCC的进展和预后中的作用。方法:采用实时荧光定量PCR法检测72例ESCC组织ITGA V的表达,并同时检测33例食管炎性组织为对照。分析ITGA V表达与ESCC癌临床病理因素之间的相关性。结果:ESCC癌组织中ITGA V的m RNA表达水平明显高于炎症组织(P<0.05),且表达水平与T、N和临床分期(P均<0.05)呈显著相关,而与患者年龄及性别无相关性。结论:ITGA V的过度表达与ESCC的转移、进展有关,ITGA V可能会成为ESCC患者个体化治疗有效的预后标志物。
OBJECTIVE: To detect the expression of integrinαv ITGA V in esophageal squamous cell carcinoma (ESCC) tissues, and to analyze the relationship between ITGA V expression and clinicopathological factors and to explore the progress and prognosis of ESGA V in ESCC In the role. Methods: The expression of ITGA V in 72 ESCC tissues was detected by real-time fluorescence quantitative PCR, and 33 esophageal inflammatory tissues were also detected as control. The correlation between ITGA V expression and clinicopathological factors of ESCC was analyzed. Results: The mRNA expression of ITGA V in ESCC was significantly higher than that in inflammatory tissue (P <0.05), and the expression level was significantly correlated with T, N and clinical stages (all P <0.05), but not with age and gender No correlation. Conclusion: The overexpression of ITGA V is related to the metastasis and progression of ESCC. ITGA V may be an effective prognostic marker for individualized treatment of patients with ESCC.