,Schisandrin B decreases the sensitivity of mitochondria to calcium ion-induced permeability transit

• 作 者: Po-yee CHIU Hoi-yan LEUNG Ada HL SIU Michel KT POON Kam-ming KO
• 机 构: Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong SAR, China
• 出 处: 中国药理学报(英文版)
• 发表日期: 2007年10期
• 关键词: schisandrin B mitochondria permeabilitytransition calcium myocardial ischemia-re

Aim: In order to elucidate the molecular mechanism underlying the cardioprotection afforded by schisandrin B (Sch B), the effect of Sch B treatment on the sensitivity of mitochondria to Ca2+-stimulated permeability transition (PT) was investigated in rat hearts under normal and ischemia-reperfusion (I-R) conditions. Results:Myocardial I-R injury caused an increase in the sensitivity of mitochondria to Ca2+-stimulated PT in vitro. The enhanced sensitivity to mitochondrial PT was associated with increases in mitochondrial Ca2+ content as well as the extent of reactive oxidant species production in vitro and cytochrome c release in vivo.The cardioprotection afforded by Sch B pretreatment against I-R-induced injury was paralleled by the decrease in the sensitivity of myocardial mitochondria to Ca2+-stimulated PT, particularly under I-R conditions. Conclusion: The results suggest that Sch B treatment increases the resistance of myocardial mitochondria to Ca2+-stimulated PT and protects against I-R-induced tissue injury.