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据Schmoller KM 2015年10月8日[Nature,2015,526(7572):268-272.]报道,美国斯坦福大学的研究人员在出芽酵母中发现在细胞分裂之前,周期蛋白Cln3的合成速率随细胞尺寸变化,而转录抑制因子Whi5的浓度会随细胞生长而得到稀释,通过这种机制实现了细胞尺寸对增殖的调控。细胞的大小是影响细胞内所有生物合成过程的基础,它决定了细胞器的尺寸还影响着细胞的物质运输。虽然大量研究已经发现了许多影响细胞大小的基因,但细胞尺寸调控之下隐藏的分子机制仍然没有得到完全揭示。
According to Schmoller KM, Oct. 8, 2015 [Nature, 2015, 526 (7572): 268-272.], Researchers at Stanford University in the United States found in budding yeast that the rate of cyclin Cln3 synthesis before cell division Size changes, and the transcriptional repressor Whi5 concentration will be diluted with the cell growth, through this mechanism to achieve the regulation of cell size on proliferation. The size of the cell is the basis of all the biosynthetic processes in the cell, which determine the size of the organelles and also the material transport of the cells. Although a large number of studies have found many genes that affect cell size, the hidden molecular mechanisms underlying cell size regulation are still not completely revealed.