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自1998年以来,我院应用低分子肝素辅助激素治疗小儿难治性肾病12例,现报告如下。 临床资料:本组12例均系原发性肾病综合征(符合1981年全国儿科肾脏疾病科研协作组制订的诊断标准),男10例,女2例;单纯性肾病7例,肾炎性肾病5例;初发6例,复发6例。12例均为难治性肾病(激素耐药8例,频繁复发4例),9例呈高凝状态。实验室检查:血小板300～600×10~9/L9例、200～300×10~9/L2例、<200×10~9/L1例;胆固醇>11.0mmol/L8例、6.11～1mmol/L4例;白蛋白<20g/L9例、20～28g/L3例;10例测血浆纤维蛋白原,>4g/L9例。
Since 1998, our hospital application of low molecular weight heparin adjuvant hormone in children with refractory renal disease in 12 cases, are as follows. Clinical data: The group of 12 cases were primary nephrotic syndrome (in line with the 1981 national pediatric kidney disease research collaboration group developed diagnostic criteria), 10 males and 2 females; simple nephropathy in 7 cases, nephritis nephropathy 5 Cases; initial 6 cases, 6 cases of recurrence. All 12 cases were refractory nephropathy (hormone resistance in 8 cases, frequent recurrence in 4 cases), and 9 cases showed hypercoagulable state. Laboratory tests: platelet 300 ~ 600 × 10 ~ 9 / L 9 cases, 200 ~ 300 × 10 ~ 9 / L2 cases, <200 × 10 9 / L1 cases; cholesterol> 11.0mmol / L8 cases, 6.11 ~ 1mmol / L4 Cases of albumin <20g / L 9 cases, 20 ~ 28g / L3 cases; 10 cases of plasma fibrinogen,> 4g / L9 cases.