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目的探讨α-Catenin在膀胱癌中的表达及其与膀胱癌生物学行为之间的关系。方法应用免疫组化SP法检测α-Catenin在35例膀胱癌和10例正常膀胱中的表达，结果10例正常膀胱均为阳性，阳性着色位于相邻上皮细胞的边缘．胞浆内无表达。α-Catenin的异常表达率为19/35（54.3%），其中G1为3/12（25％）；G2为7/13（53.9%);G3为9/10（90%）。TA～T1为5/13（38.5%）；T2～T3为10／11（90.9%）、不同的分期分级间均有显著性差异。4例术后一年内死亡的患者α-Catenin表达均为阴性，与存活期超过一年者相比亦有显著性差异.结论α-Catenin的低表达可能在膀胱癌的进展中起着重要作用；检测其表达对膀胱癌的诊断和预后有一定临床意义。
Objective To investigate the expression of α-Catenin in bladder cancer and its relationship with the biological behavior of bladder cancer. Methods The expression of α-Catenin in 35 cases of bladder cancer and 10 cases of normal bladder was detected by immunohistochemical SP method. All 10 cases of normal bladder were positive, and positive staining was located on the edge of adjacent epithelial cells. No expression in cytoplasm. The abnormal expression rate of α-Catenin was 19/35 (54.3%), among which G1 was 3/12 (25%); G2 was 7/13 (53.9%); G3 was 9/10 (90%). TA ~ T1 was 5/13 (38.5%); T2 ~ T3 was 10/11 (90.9%). There were significant differences among different staging grades. The expression of α-Catenin in 4 patients who died within one year after surgery was negative, which was also significantly different from the survival time of more than one year.Conclusions The low expression of α-Catenin may play an important role in the progression of bladder cancer ; Detection of its expression of bladder cancer diagnosis and prognosis of a certain clinical significance.