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流行性脑脊髓膜炎(流脑)的暴发型在流脑发病中约占0.5～10%,起病急骤,发展迅速,病情凶险,如诊断治疗不及时,常可于24小时内死亡,其死亡率国外报道为50～70%,国内近年来用654-2抢救后仍可达5～20%,故应引起重视。暴发型流脑的发病机理暴发型流脑发病的确切机制不完全明了,近年来随着对微循环的研究和认识深入,一般均认为脑膜炎双球菌的内毒素主要作用于皮肤、内脏的微血管,引起全身微循环障碍的属暴发休克型(内毒素休克);发生在脑
Outbreak of epidemic cerebrospinal meningitis (meningitis) in the incidence of meningitis accounted for about 0.5 to 10%, rapid onset, rapid development, dangerous condition, such as diagnosis and treatment is not timely, often within 24 hours of death, its Mortality rate of 50 to 70% foreign reports, the domestic use of 654-2 in recent years after the rescue is still up to 5 to 20%, it should be taken seriously. The pathogenesis of fulminant meningitis The exact mechanism of fulminant meningitis is not entirely clear, in recent years with the microcirculation research and understanding, generally considered meningococcus endotoxin main role in the skin, visceral microvascular , Causing systemic microcirculation disorder is an outbreak of shock (endotoxic shock); occurs in the brain