论文部分内容阅读
自1972年Magnius及Espmark发现HBeAg以来,虽经广泛研究,但它和HBV的组成关系仍不清楚。HBeAg仅见于HBsAg阳性血清。近年来的研究认为HBeAg是HBV核心的一个亚成分或其裂解产物。HBeAg阳性血清常伴有高滴度的HBV及与HBV相关的血清学指标,如Dane颗粒、DNA多聚酶活性及HBV的DNA等。流行病学资料证明HBeAg与肝病的活动性和高度感染性相关。本文应用放射免疫方法(RIA)检测HBeAg及抗-HBe,观察慢性乙型肝炎中e系统的消长过程以及它和临床表现的关系。观察对象是25名慢性乙型肝炎病人,全
Although extensive studies have been conducted since the discovery of HBeAg by Magnius and Espmark in 1972, its composition with HBV remains unclear. HBeAg is found only in HBsAg-positive sera. Recent studies suggest that HBeAg is a sub-component of the HBV core or its cleavage product. HBeAg-positive serum is often accompanied by high titers of HBV and serological markers associated with HBV such as Dane granules, DNA polymerase activity and HBV DNA. Epidemiological data demonstrate that HBeAg is associated with high activity and highly infectious liver disease. In this paper, radioimmunoassay (RIA) was used to detect HBeAg and anti-HBe, to observe the growth and decline of e system in chronic hepatitis B and its relationship with clinical manifestations. The observation object is 25 patients with chronic hepatitis B, all