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目的 分析肾活检及相关实验室检测结果 ,探讨儿童狼疮性肾炎 (LN)病理类型与临床表现的关系。方法 对 3 5例LN患者进行肾活检及常规实验室检查 ,根据WHO1982年标准进行病理分型。结果 病理类型以Ⅳ型LN最多 ,占 3 7 4% ,其次是Ⅴ型 (3 1 4% )和Ⅲ型 7例 (2 0 0 % )。Ⅳ型和Ⅴ型多表现为肾病综合征 ,Ⅱ型与Ⅲ型多表现为肾炎综合征。Ⅳ型LN的高血压、肾功能不全发生率最高。LN肾间质受累程度较轻微 ,以Ⅳ型最为显著。血Cr水平与肾间质受累程度呈正相关。结论 儿童期LN临床表现及病理检查均有一定的特点 ,两者有一定的关系 ,积极行肾活检对指导治疗与估计预后有重要意义。
Objective To analyze the results of renal biopsy and related laboratory tests and investigate the relationship between pathological types and clinical manifestations in children with lupus nephritis (LN). Methods Thirty-five LN patients underwent renal biopsy and routine laboratory tests, and were divided into two groups according to WHO 1982 standard. Results Most of the pathological types were type Ⅳ LN, accounting for 37.4%, followed by type Ⅴ (31.4%) and type Ⅲ 7 (20%). Type â ... ¢ and â ... â ... ¡type showed more than nephrotic syndrome, type â ... ¡and â ... ¢ type showed more nephritic syndrome. Type Ⅳ LN, the highest incidence of renal insufficiency. LN renal interstitial involvement is minor, the most obvious type Ⅳ. Blood Cr levels and renal interstitial involvement was positively correlated. Conclusions The clinical manifestations and pathological findings of LN in childhood all have certain characteristics. Both of them have a certain relationship. The positive renal biopsy is of great significance for guiding treatment and estimating the prognosis.