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探讨哮喘患儿诱导痰液中IL 8测定的临床意义。采用ELISA法分别测定 4 1例不同时期、不同程度的哮喘患儿和 11例正常儿童诱导痰液中IL 8含量 ,便携式肺功能仪测定肺通气功能。哮喘组患儿诱导痰液中IL 8含量较对照组显著增高 ,P <0 0 5 ;中、重度发作期哮喘患儿诱导痰液IL 8含量较稳定期显著增高 ,P <0 0 5。诱导痰液中IL 8含量与 1s用力呼气容积占预计值百分比 (FEV1 0 % )呈显著负相关。IL 8参与了儿童哮喘的发生和发展 ,诱导痰液中IL 8含量可反映气道炎症的变化 ,可用于儿童哮喘发病机制的研究、病情监测及指导药物治疗
To investigate the clinical significance of IL-8 in induced sputum in children with asthma. The levels of IL-8 in sputum were measured by ELISA in 41 children with asthma and 11 normal children at different stages, respectively. Pulmonary ventilation was measured by portable lung function analyzer. The levels of IL 8 in induced sputum in asthmatic children were significantly higher than those in control group (P <0.05). IL-8 levels in induced sputum of asthmatic children were significantly higher than those in control group (P <0.05). Induced sputum IL 8 content and 1s forced expiratory volume accounted for the expected percentage (FEV1 0%) was significantly negatively correlated. IL 8 is involved in the development and progression of childhood asthma. Induction of IL-8 in sputum can reflect the changes of airway inflammation, which can be used in the pathogenesis of asthma in children, monitoring the disease and guiding drug therapy