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目的观察催产素联合地诺前列酮对足月胎膜早破的引产效果。方法 427例足月胎膜早破患者,随机分为两组,对照组223例按常规方法给予催产素静脉注射引产,治疗组204例给予催产素联合地诺前列酮静脉注射引产;观察两组产妇与新生儿结局。结果治疗组12 h、24 h内阴道分娩高于对照组(P<0.05);两组12 h内活跃期比例、活跃期时间均高于或长于对照组(P<0.05);两组的引产-分娩间隔时间及子宫张力过高、子宫收缩过频、子宫过度刺激、羊水污染比例、不良反应、并发症发生率差异均统计学意义(P>0.05);两组胎儿黄疸、新生儿Apgar评分、新生儿体重、入院指证比例比较,差异均无统计学意义(P>均0.05)。结论地诺前列酮联合催产素用于足月胎膜早破引产安全、有效。
Objective To observe the induction effect of oxytocin and dinoprostone on full-term premature rupture of membranes. Methods A total of 427 patients with full-term premature rupture of membranes were randomly divided into two groups. In the control group, 223 cases were given oxytocin intravenously by conventional method. In the treatment group, 204 cases were given oxytocin and dinoprostone intravenously. Maternal and neonatal outcomes. Results The intractable vaginal delivery within 12 h and 24 h in the treatment group was significantly higher than that in the control group (P <0.05). The proportion of active phase and the active phase within 12 h in both groups were significantly higher than those in the control group (P <0.05) (P> 0.05). There was significant difference between the two groups in fetal jaundice, neonatal Apgar score, neonatal jaundice rate, neonatal infantile jaundice rate, , The weight of newborn and the proportion of admission evidence, there was no significant difference (P> 0.05). Conclusions Dinoprostone combined with oxytocin is safe and effective for full-term premature rupture of membranes.