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目的观察川芎嗪注射液对急性脑梗死患者血清高敏C反应蛋白(hs-CRP)的影响。方法将64例急性脑梗死患者采用随机数字表法分为观察组(32例)和对照组(32例),对照组予常规治疗,观察组在对照组治疗基础上加用川芎嗪注射液治疗,连续治疗14 d,比较两组神经功能缺损(NIHSS)、日常生活能力(ADL)评分和血清高敏C反应蛋白(hs-CRP)的变化。结果治疗前,两组患者NIHSS、ADL评分和血清hs-CRP水平比较,差异无统计学意义(P>0.05)。治疗后两组ADL评分均明显升高,观察组显著高于对照组(P<0.05),两组患者NIHSS评分和血清hs-CRP水平均明显下降,观察组较对照组下降更显著(P<0.05)。结论川芎嗪对急性脑梗死有良好的治疗作用,其作用机制可能与降低患者血清hs-CRP水平、抑制炎症反应有关。
Objective To observe the effect of ligustrazine injection on serum high sensitive C-reactive protein (hs-CRP) in patients with acute cerebral infarction. Methods Sixty-four patients with acute cerebral infarction were divided into observation group (32 cases) and control group (32 cases) by random number table. The control group was given conventional treatment. The observation group was treated with ligustrazine on the basis of the control group For 14 days. The NIHSS, ADL score and serum hs-CRP level were compared between the two groups. Results Before treatment, there was no significant difference in NIHSS, ADL score and serum hs-CRP level between the two groups (P> 0.05). After treatment, the ADL scores of the two groups were significantly increased, the observation group was significantly higher than the control group (P <0.05), NIHSS score and serum hs-CRP levels were significantly decreased in both groups, the observation group decreased more significantly than the control group (P < 0.05). Conclusion Tetramethylpyrazine has a good therapeutic effect on acute cerebral infarction. Its mechanism may be related to reducing serum hs-CRP level and inhibiting inflammatory reaction.