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目的:研究1 8F-FB-RGD在Lewis肺癌模型体内的生物分布。方法:24只荷Lewis肺癌C57BL/6小鼠随机分为实验组和对照组(每组12只),实验组和对照组经尾静脉分别注射示踪剂18F-FB-RGD和18F-FDG,并在注药后不同时相点(30、60、90、120min)分别测量血液及各主要组织器官(心、肝、脾、肺、肾、小肠、脑、肿瘤)中的放射性浓度,获得其体内生物学分布数据。结果:(1)在1 8F-FB-RGD的生物分布研究中,肿瘤部位有相当高的放射性摄取,肿瘤对血、肌肉及肺的T/NT比值均大于2.0。(2)示踪剂1 8F-FB-RGD对包括原发肿瘤和对侧肺转移瘤都作出了清晰显像;1 8F-FDG则由于心脏高摄取及肺部的高本底而无法区分肿瘤与纵隔,特异性不强,而且未发现转移瘤,灵敏度较1 8F-FB-RGD差。结论:同1 8F-FDG相比,1 8F-FB-RGD示踪剂对肺癌显影具有更高的特异性和灵敏性,有望成为肿瘤受体显影的高敏感性特异性示踪剂,在肺癌诊断、分期、转移和疗效监测方面发挥重要作用。
OBJECTIVE: To study the biodistribution of 1 8F-FB-RGD in Lewis lung carcinoma model. Methods: Twenty-four Lewis lung carcinoma C57BL / 6 mice were randomly divided into experimental group and control group (12 in each group). Tracer 18F-FB-RGD and 18F-FDG were injected into tail vein of experimental group and control group, The radioactive concentrations in blood and major tissues and organs (heart, liver, spleen, lung, kidney, small intestine, brain and tumor) were measured at different time points (30, 60, 90, 120min) In vivo biological distribution data. Results: (1) In the biodistribution study of 18F-FB-RGD, there was a fairly high radioactive uptake at the tumor site. The T / NT ratios of tumor to blood, muscle and lung were both greater than 2.0. (2) Tracer 1 8F-FB-RGD clearly demonstrated both primary and contralateral lung metastases; 18F-FDG was unable to differentiate tumors due to high cardiac uptake and high lung background And mediastinum, the specificity is not strong, and no metastases were found, the sensitivity is worse than 1 8F-FB-RGD. CONCLUSION: The 1 8F-FB-RGD tracer has higher specificity and sensitivity for lung cancer imaging than 1 8F-FDG and is expected to become a highly sensitive and specific tracer for tumor receptor development. Diagnosis, staging, metastasis and efficacy monitoring play an important role.