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在一些成人T细胞白血病(ATL)患者中发生难治性腹泻,并常导致严重衰弱,这种难治性腹泻的主要原因之一被认为是ATL细胞向胃肠道扩散和广泛浸润。5例未经治疗的ATL伴白血病细胞向胃肠道浸润的患者于1981年12月-1983年7月接受了胃肠道X线、内窥镜和病理学检查。作者对他们进行了回顾性研究。 5例患者均为男性,年龄为43-67岁。病例3、4和5主要表现为难治性腹泻,病例1为上腹部疼痛。5例患者均有外周淋巴结病。5例患者的白血病细胞都具有羊红细胞受体,对T细胞特异性单克隆抗体OKT4均显示阳性反应。胃部X线检查发现,病例1显示硬癌样阴影;病例2在穹窿部有不规则网状阴
Refractory diarrhea occurs in some adult T-cell leukemia (ATL) patients and often leads to severe debilitating. One of the major causes of this refractory diarrhea is thought to be the proliferation and extensive infiltration of ATL cells into the gastrointestinal tract. Five untreated ATL patients with leukemia infiltrating into the gastrointestinal tract underwent gastrointestinal X-ray, endoscopy, and pathology from December 1981 to July 1983. The authors conducted a retrospective study of them. All 5 patients were male, aged 43-67 years. Cases 3, 4, and 5 predominate as refractory diarrhea and case 1 as upper abdominal pain. Five patients had peripheral lymphadenopathy. All 5 leukemia cells had a sheep red blood cell receptor, which showed a positive response to T cell-specific monoclonal antibody OKT4. Gastric X-ray examination revealed that case 1 showed a hard-cancer-like shadow; case 2 had an irregular reticular form in the fornix