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本文评价β阻滞剂卡维地洛(Carvedilol,CDL)2种剂量对慢性稳定型心绞痛病人的影响。20例慢性稳定型心绞痛病人,研究前10天除舌下含服硝酸甘油外停用一切抗心绞痛药。先口服安慰剂每日2次(2周),然后口服CDL25mg每日2次(2周),再口服CDL 50mg每日2次(2周),最后口服安慰剂(2周)。 CDL2种剂量能使平均静息和运动心率、血压下降,与安慰剂有显著差异,且静息心率和血压及运动时舒张压呈剂量依赖性降低。口服安慰剂、CDL 2种剂量时静息射
This article evaluates the effects of two doses of beta blocker, Carvedilol (CDL), on patients with chronic stable angina. Twenty patients with chronic stable angina were stopped using all antianginal drugs except sublingual nitroglycerin 10 days before the study. The first oral placebo twice daily (2 weeks), then oral CDL25mg twice daily (2 weeks), and then oral CDL 50mg twice daily (2 weeks), the last oral placebo (2 weeks). CDL2 doses resulted in a significant difference in mean resting and exercise heart rate, blood pressure, and placebo, with resting heart rate and blood pressure and diastolic blood pressure during exercise in a dose-dependent manner. Oral placebo, CDL 2 doses when resting shot