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在一个相当长的时期内,医学界认为肺仅仅是一个呼吸器官。直到1887年 Bohr 才指出肺不仅仅是一个氧和二氧化碳交换的器官。至1953年 Gaddum 证实肺有减活5-HT的作用后,才逐渐认识到肺参与许多生物活性物质的合成、降解、移除与释放某些物质的作用。近10年来医务工作者得到一个概念,即肺不仅是一个呼吸器官而且是一个复杂的代谢器官。由于肺对机体内许多内分泌素和介质有代谢和调节作用,且这些物质对维持机体内环境稳定有重要作用。故一旦这些物质在体内的生化代谢发生障碍,就会使肺疾患的病人出现肺以外某些系统的功能发生紊乱,这一点为说明肺部疾患及肺外的症状与体征提供新的依据,必将使肺部疾患的诊断与治疗取得新的进展。肺的非呼吸功能有其微细结构作基础,近年来发现肺内一些新的细胞参与代谢及
For a long period of time, the medical community considered the lungs to be just a respiratory organ. It was not until 1887 that Bohr pointed out that the lungs were more than just an organ of oxygen and carbon dioxide exchange. Until 1953, Gaddum confirmed that the lungs have the role of deactivating 5-HT, and gradually came to realize that the lungs are involved in the synthesis, degradation, removal and release of certain substances by many bioactives. In the past 10 years, medical workers get the concept that the lungs are not only a respiratory organ but also a complex metabolic organ. As the lungs have many metabolic and regulatory effects on many endocrine and mediators in the body, these substances play an important role in maintaining a stable environment in the body. So once these substances in the body of biological and metabolic disorders, it will enable patients with lung disease appeared outside the lungs some of the system dysfunction, which is to explain the lung disease and extra-pulmonary symptoms and signs provide a new basis will New progress will be made in the diagnosis and treatment of pulmonary diseases. Lung non-respiratory function has its microstructure as the basis, in recent years found that some new lung cells involved in metabolism and