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目的:观察蛋白质精氨酸甲基转移酶5(PRMT5)和驱动蛋白超家族23(KIF23)在结直肠癌的癌组织中表达，探讨PRMT5和KIF23的表达水平与结直肠癌病理特征的关系。方法:收集2015年5月至2020年5月惠州市中心人民医院联合广东医科大学附属医院经病理学确诊的结直肠癌组织标本及对应癌旁正常组织标本93例，采用免疫组织化学法检测当中组织的PRMT5和KIF23表达，组间比较采用n χ2检验。n 结果:结直肠癌的癌组织中PRMT5表达率为72.04%(67/93)，显著高于癌旁正常组织中PRMT5表达率17.20%(16/93)，两者比较差异有统计学意义(n χ2＝56.590，n P<0.01)；结直肠癌的癌组织中KIF23表达率63.44%(59/93)，显著高于癌旁正常组织中KIF23表达率12.90%(12/93)，两者比较差异有统计学意义(n χ2＝50.321，n P<0.01)。PRMT5表达水平和结直肠癌的组织学分化程度、淋巴结转移、肿瘤淋巴结转移(TNM)分期呈明显相关(n χ2＝6.364、7.107、5.415，n P<0.05)，KIF23表达水平和结直肠癌的浸润深度、组织学分化程度、淋巴结转移、TNM分期呈明显相关(n χ2＝5.911、4.543、7.560、4.1560，n P<0.05)。n 结论:PRMT5和KIF23在结直肠癌的癌组织中呈高表达，与结直肠癌临床病理特征具有一定关系。“,”Objective:To investigate the expression of protein arginine methyltransferase 5 (PRMT5), kinesin family member 23 (KIF23) in colorectal carcinoma (CRC) tissues, and their correlation with the clinicopathological features of CRC.Methods:The expression levels of PRMT5 and KIF23 in 93 cases of CRC tissues and adjacent colorectal tissues of patients pathologically confirmed from May 2015 to May 2020 on Huizhou Municipal Central Hospital and Affiliated Hospital of Guangdong Medical University were examined by envision immunohistochemical method. The statistical analysis of n χ2 test in combination with clinical data was carried out.n Results:The expression rate of PRMT5 was 72.04% (67/93) in CRC tissues, significantly higher than that [17.20% (16/93)] in non-cancerous adjacent colorectal tissues (n χ2=56.590, n P<0.01). The expression rate of KIF23 was 63.44% (59/93) in CRC tissues, significantly higher than that [12.90% (12/93)] in non-cancerous adjacent colorectal tissues (n χ2=50.321, n P<0.01). The expression of PRMT5 was related CRC to histology grade, TNM stage, and lymph node metastasis (respectively,n χ2=6.364, 7.107, 5.415, n P<0.05). The expression rate of Foxp3 was 80.20% (81/101) in CRC tissues, and 34.6% (35/101) in non-cancerous adjacent colorectal tissues (n t=42.846, n P<0.01). The expression of KIF23 was related CRC to histology grade, serosa invasion, tumour node metastases (TNM) stage and lymph node metastasis (respectively,n χ2=5.9114, 4.5428, 7.5598, 4.1557, n P<0.05).n Conclusion:PRMT5 and KIF23 are highly expressed in CRC tissues. PRMT5 and KIF23 have a certain relationship with clinicopathological features of CRC.