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目的:分析我院发生药品不良反应(ADR)的主要品种类别,为临床合理用药提供参考,减少ADR的发生。方法:对我院2008～2011年收集的136例ADR报告进行统计分析,列举不良反应的药品主要类别、例数、多发药品及临床表现。结果:136例ADR中,以女性多于男性,≥60岁的患者占41.18%,≤10岁的患者占39.71%;抗菌药和中药制剂在药品种数上稳居前2位。抗菌药引起ADR最为多见,占48.53%,其次是中药制剂,占40.44%;给药途径以静脉给药引起的ADR为主;皮肤及其附件损害最多,占53.68%结论:应严格按照《抗菌药物临床应用指导原则》合理使用抗菌药,同时应规范中药制剂的临床应用,加强有关中药安全用药知识的普及,从而保障患者用药安全、有效。
OBJECTIVE: To analyze the main categories of adverse drug reaction (ADR) in our hospital and provide a reference for clinical rational drug use to reduce the occurrence of ADR. Methods: The data of 136 ADR cases collected in our hospital from 2008 to 2011 were analyzed. The main categories, number of cases, multiple drugs and clinical manifestations of adverse drug reactions were listed. Results: Among 136 cases of ADR, 41.18% were female and more than 60 years old, and 39.71% were ≤10 years old. The number of antibacterials and traditional Chinese medicines ranked the top two in the number of drugs. Antibiotics cause the most ADR, accounting for 48.53%, followed by traditional Chinese medicine preparations, accounting for 40.44%; route of administration to intravenous administration caused by ADR; skin and its accessories most damage, accounting for 53.68% Conclusion: Should be strictly in accordance with the “ Antibiotics Clinical Guidelines ”rational use of antimicrobial agents, and should standardize the clinical application of traditional Chinese medicine preparations to strengthen the popularization of knowledge about the safety of traditional Chinese medicine, so as to protect patients safe and effective medication.