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目的了解常见生化指标和急性脑梗死患者严重程度的相关性。方法连续收集发病7d内住院的急性脑梗死患者430例,记录危险因素、检验生化指标,按照NIHSS评分分为轻、重型脑梗死,比较两组间生化指标的差异。结果共入选30例急性脑梗死病人,其中,轻型225例(52.30%),重型205例(47.70%),平均年龄69.36±11.28岁;重型脑梗死组中CHOL、LDL-C、BUN、UA、WBC、FIB浓度显著高于轻型脑梗死组;Logistic回归分析结果显明,UA、WBC、LDL-C水平升高及HDL-C水平降低是发生重型脑梗死的重要危险因素。结论UA、WBC、LDL-C水平升高及HDL-C水平降低可能与发生脑梗死后的严重程度有关,临床上要注意综合评估这些生化指标并予以控制。
Objective To understand the correlation between common biochemical indicators and the severity of acute cerebral infarction. Methods A total of 430 patients with acute cerebral infarction who were hospitalized within 7 days after onset were enrolled. The risk factors were recorded and the biochemical indexes were tested. The NIHSS scores were divided into mild and severe cerebral infarction. The differences of biochemical indexes between the two groups were compared. Results A total of 30 patients with acute cerebral infarction were enrolled in this study. Among them, 225 (52.30%) were mild and 205 (47.70%) were heavy, with an average age of 69.36 ± 11.28 years. CHOL, LDL- C, BUN, UA, WBC and FIB were significantly higher than those of mild cerebral infarction group. Logistic regression analysis showed that elevated UA, WBC, LDL-C and decreased HDL-C levels were important risk factors for severe cerebral infarction. Conclusions UA, WBC, LDL-C levels and HDL-C levels may be related to the severity of cerebral infarction. Clinicians should pay attention to the comprehensive evaluation of these biochemical parameters and to control them.