论文部分内容阅读
法国巴黎Tenon医院放射肿瘤科1980年～1992年在BMT之前行TBI处理494例。年龄2～63岁;男女之比1.6:1;平均和中位随访时间分别为62月(24～130月)和60月。患者中ALL139例(28％)。ANLL177例(36％)。254例(51％)为首次CR;118例(24％)为第二次CR。TBI技术分两组;一次照射TBI(STBI)291例(59％),L_4中平面剂量10Gy,4～6小时给予,肺用局部防护后受量限制在8Gy。分次照射TBI(FTBI)203例(41％),剂量12Gy/6次,连续3天,L_4水平计算剂量,肺受量9Gy。两组随访时间无差别。 结果:5年(和10年)全组及无病生存率分别为46(43％)和38％(35％)。42例(8.9％)出现白内障;5年
Radiation Oncology, Tenon Hospital, Paris, France, 494 patients underwent TBI before BMT from 1980 to 1992. Age ranged from 2 to 63 years. The ratio of men to women was 1.6: 1. Mean and median follow-up time was 62 months (24 to 130 months) and 60 months respectively. ALL patients in patients with 139 cases (28%). ANLL177 cases (36%). 254 cases (51%) for the first CR; 118 cases (24%) for the second CR. The TBI technique was divided into two groups: 291 cases (59%) of TBI (one irradiation), 10Gy of mid-plane dose of L_4, 4 to 6 hours after TBI, and 8Gy after lung protection. 203 (41%) TBI (41%) were irradiated by graded irradiation at a dose of 12 Gy / day for 3 consecutive days. There was no difference between the two groups in follow-up time. Results: The 5-year (and 10-year) overall and disease-free survival rates were 46 (43%) and 38% (35%), respectively. 42 cases (8.9%) had cataract; 5 years