论文部分内容阅读
目的观察通心络胶囊联合辛伐他汀对颈动脉不稳定粥样斑块的影响。方法符合入选标准的50例患者都随机分为两组,每组25例,对照组为辛伐他汀常规治疗组。通心络治疗组为在辛伐他汀常规治疗的基础上加用通心络胶囊,每天3次,每次3粒,饭后服用。治疗6个月及12个月前后测TC、TG、HDL、LDL及颈动脉粥样硬化斑块的变化,并与常规治疗组进行对照,同时记录不良事件情况。结果①组患者在性别年龄及斑块数目体积等方面比较并无显著意义(P>0.05)。②25例通心络治疗6个月后TC、TG、LDL明显低于治疗前水平,HDL高于治疗前水平,颈动脉粥样斑块厚度缩小,面积缩小,12个月后上述各项指标改变更为明显,与常规治疗组相比较差异有显著性(P<0.01)。结论通心络胶囊联合辛伐他汀能有效调节血脂防治动脉硬化及稳定斑块有重要作用。
Objective To observe the effect of Tongxinluo capsule combined with simvastatin on unstable plaque in carotid artery. Methods Fifty patients who met the inclusion criteria were randomly divided into two groups of 25 patients each, and the control group was simvastatin conventional treatment group. Tongxinluo treatment group in the routine treatment of simvastatin plus Tongxinluo capsules, 3 times a day, each 3, taking after meals. The changes of TC, TG, HDL, LDL and carotid artery atherosclerotic plaques were measured at 6 months and 12 months after treatment. The changes of carotid atherosclerotic plaque were compared with those of the conventional treatment group and the adverse events were recorded. Results ① There was no significant difference in sex age, number of plaques and other aspects between the two groups (P> 0.05). ② The TC, TG, LDL of 25 patients treated with Tongxinluo were significantly lower than those before treatment, the HDL was higher than the pretreatment level, the carotid artery atherosclerotic plaque size was reduced and the area was reduced. After 12 months, the above indexes changed More significantly, compared with the conventional treatment group, the difference was significant (P <0.01). Conclusion Tongxinluo capsule combined with simvastatin can effectively regulate blood lipid and prevent atherosclerosis and stabilize plaque plays an important role.