论文部分内容阅读
在小鼠,调控免疫反应的基因属于主要组织相容性H-2复合体的Ir基因。在一些纯系小鼠株中,对某一特定抗原,有的小鼠株只产生原发性的IgM反应,而不产生继发性的免疫记忆反应(非反应者),有的小鼠株可产生上述两种反应(反应者)。目前,只知道由Ir基因调控的特异性免疫反应仅局限于胸腺依赖性抗原,还没有报道Ir基因对胸腺非依赖性抗原反应的调控作用。本文作者发现,在一些纯系小鼠株中,产生对一种胸腺非依赖性抗原TNP-LPS的反应,有许多
In mice, the genes that regulate the immune response belong to the Ir gene of the major histocompatibility H-2 complex. In some pure strains of mice, some mouse strains of a particular antigen, only produce primary IgM reaction, but not secondary immune memory reaction (non-responders), and some mouse strains Both reactions (responder) can be generated. Currently, it is only known that the specific immune response regulated by the Ir gene is confined to the thymus-dependent antigen, and no regulation of the Ir gene on the thymus-independent antigen reaction has been reported. The authors found that in some strains of pure-line mice, the response to one of the thymus-independent antigens, TNP-LPS, occurred in many