论文部分内容阅读
研究了甲基黄酮丙醇胺酰胺盐酸盐(SIPI-644)对电刺激家兔左心室致颤阈值(VFT)的影响,并在等毒剂量下同甲基黄酮丙醇胺盐酸盐(SIPI-549)、胺碘酮盐酸盐(Ami)、利多卡因(Lid)和奎尼丁(Qui)等药物进行了比较。结果表明,SIPI-644在iv1.8～14.4mg/kg(0.0125～0.1LD_(50))剂量范围内包括对正常心脏、急性缺血心脏、和阻滞植物神经系统的缺血心脏均能明显提高VFT值,且对正常心脏其作用与剂量呈线性相关关系。在0.1LD_(50)剂量时,SIPI-644使VFT提高的程度显著高于各对照组,其急性毒性明显低于Lid、Qui和SIPI-549,同Ami近似。
The effect of SIPI-644 on left ventricular fibrillation threshold (VFT) in rabbits was investigated. The effects of SIPI-644 on ventricular fibrillation threshold (VFT) SIPI-549), amiodarone hydrochloride (Ami), lidocaine (Lid) and quinidine (Qui) and other drugs were compared. The results showed that SIPI-644 could significantly increase the dosage of iv1.8 ~ 14.4mg / kg (0.0125 ~ 0.1LD_ (50)) in normal heart, acute ischemic heart, and ischemic heart with autonomic nerve system Improve the VFT value, and the role of normal heart and dose-related linearly. At the dose of 0.1 LD50, SIPI-644 increased the VFT significantly higher than that of the control group. The acute toxicity of SIPI-644 was significantly lower than that of Lid, Qui and SIPI-549, which was similar to Ami.