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目的:评价不同年龄段宫颈病变患者检测人乳头状瘤病毒(HPV)感染状况的临床意义。方法:对妇产科门诊及住院宫颈病变患者174例作宫颈组织病理检查,采用PCR-反向点杂交法检测宫颈病变患者感染的HPV不同亚型。结果:174例HPV感染者分为高危型HPV及多重感染153例,以HPV 16、52、58型最常见。高危型与低危型HPV混合感染3例,低危型HPV及多重感染18例,以6、11、43型多见,中国特有的高危型CP8304共4例。高危型HPV及多重感染与低危型HPV及多重感染组相比宫颈病变程度的差异均有统计学意义(P<0.05),患宫颈癌风险增加,尤其是31~50岁的患者。结论:HPV检测可用于临床筛查及病情判断,对感染HPV特别是高危型HPV应高度重视,做到早诊断、早阻断、及时、全程治疗,定期复查追踪预防宫颈癌的发生。
Objective: To evaluate the clinical significance of detecting human papillomavirus (HPV) infection in cervical lesions of different ages. Methods: A total of 174 cases of obstetrics and gynecology outpatients and inpatients with cervical lesions were examined for cervical histopathology. Different subtypes of HPV in patients with cervical lesions were detected by PCR-reverse dot blot hybridization. Results: 174 cases of HPV infection were divided into high-risk HPV and multiple infections in 153 cases, the most common HPV 16,52,58 type. High-risk and low-risk HPV infection in 3 cases, low-risk HPV and multiple infections in 18 cases, 6,11,43 type more common, China’s unique high-risk type CP8304 a total of 4 cases. The difference of cervical lesions between high-risk HPV and multiple infection and low-risk HPV and multiple infection groups were statistically significant (P <0.05), and the risk of cervical cancer increased, especially in patients aged 31 to 50 years. Conclusion: HPV test can be used in clinical screening and disease judgment. HPV infection, especially high-risk HPV should be attached great importance to early diagnosis, early block, timely, full treatment, regular follow-up to prevent the occurrence of cervical cancer.