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已知很多重金属可以影响实验动物的免疫系统,其中如镉可抑制IgG抗体产生,它作用的靶细胞可能是辅助T细胞。作者研究镉之亚致死剂量的急性效应,用组织病理学方法观察给镉后对胸腺和淋巴组织的影响。作者用氯化镉溶液给雄性BALB/C小鼠腹腔注射(1.8 mg/kg),对照组小鼠注射生理盐水,在注射后的1、2、3、4、9、14天将动物处死,取出胸腺,脾脏和肠系膜淋巴结进行称重,同时对肝、肾及睾丸进行组织学检查。实验结果表明,小鼠在注射镉1～3天后,体重明显下降,1～4天后,胸腺重量明显降低,第三天重量下降到最低,2～3天后胸腺重量与全身重之比明显下降为对照组的35～55％,以后胸腺重量逐
It is known that many heavy metals can affect the immune system of experimental animals, in which cadmium, for example, inhibits the production of IgG antibodies, and its target cells may be helper T cells. The authors studied the acute effects of sublethal doses of cadmium, and observed the effects of cadmium on thymus and lymphoid tissues by histopathological methods. Male BALB/C mice were intraperitoneally injected with cadmium chloride solution (1.8 mg/kg). Control mice were injected with saline and animals were sacrificed 1, 2, 3, 4, 9, and 14 days after injection. Thymus, spleen, and mesenteric lymph nodes were removed for weighing, and histological examinations of the liver, kidney, and testis were performed. The experimental results showed that after 1 to 3 days of cadmium injection, the body weight of mice decreased significantly. After 1 to 4 days, the weight of thymus decreased significantly, and the weight on the third day dropped to the lowest. After 2 to 3 days, the ratio of thymus weight to total body weight decreased significantly. 35 to 55% of the control group, after the weight of the thymus