人大肠癌细胞株（HT29）与人多器官血管内皮细胞粘附数目及形态学观察

• 作 者: 杨学皆 朱梅刚 丁彦青 李春德 张盛 安连兵
• 出 处: 第一军医大学学报
• 发表日期: 1995年04期
• 关键词: 大肠癌细胞株 HT29 血管内皮细胞 肠系膜静脉 微绒毛 计学 模拟体 细胞转移 血道转移 恶性行为

为了模拟体内癌细胞与血管内皮粘附的过程，用人大肠癌细胞与人多器官血管内皮细胞共同培养，观察到与不同血管内皮粘附的癌细胞数有显著性统计学差异（Ｐ＜０．０５—０．０１）。与门静脉、肠系膜静脉内皮粘附的癌细胞数多，细胞表面微绒毛多，丝状突起细长，伪足多且长；与大隐静脉内皮粘附的癌细胞数少，细胞表面突起也细小。这表明不同的血管内皮对癌细胞的粘附是具有选择性的。

In order to simulate the process of adhesion between cancer cells and vascular endothelium in vivo, human colon cancer cells were co-cultured with human multi-organ vascular endothelial cells, and significant differences in the number of cancer cells adhered to different vascular endothelium were observed (P<0. 05-0.01). The number of cancer cells adhering to the portal vein and mesenteric venous endothelium is many, and there are many microvilli on the cell surface. The filamentous projections are slender, and the pseudopods are numerous and long; the number of cancer cells adhering to the great saphenous vein endothelium is small, and the cell surface protrusions are also small . This indicates that different vascular endothelium are selective for the adhesion of cancer cells.