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实验观察外源性一氧化碳 (CO)对大鼠离体肺动脉环低氧性收缩反应 (HPV)的影响 ,并通过观察血红素氧化酶抑制剂ZnPPIX对HPV的影响 ,探讨内源性一氧化碳在HPV中的作用及机制 ,结果显示 :低氧可使苯肾上腺素(PE)预收缩的肺动脉环出现明显收缩反应 ,肺动脉cGMP含量下降 ;用ZnPPIX孵
The effect of exogenous carbon monoxide (CO) on hypoxic contraction (HPV) in isolated rat pulmonary artery rings was observed and the effect of heme oxygenase inhibitor ZnPPIX on HPV was investigated. The results showed that: Hypoxia can make phenylephrine (PE) precontracted pulmonary artery ring significantly contractile response, pulmonary cGMP decreased; with ZnPPIX hatch