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在控制药物释放的高分子聚合物植入剂中,聚2-羟乙基丙烯酸甲酯[Poly(HEMA)]凝胶的应用已作了广泛研究。该凝胶一般是在水存在下以单体原料2-羟乙基甲基丙烯酸酯(HEMA)的游离基聚合而成。游离基的聚合有下列几种方法:(1)化学催化;(2)在光敏化学制剂存在下以紫外线照射;(3)离子幅射。前两者缺点是必须从凝胶中除去化学品,否则与生物组织会发生生物相容性的问题;另一缺点是,化学品可能与聚合键产生交互作用影响凝胶的网状结构而改变凝胶的溶胀性质。本文比较了采用γ-射线照射以及用化学方法所制得的聚合物的溶胀性。凝胶的制备:单体HEMA与交联剂乙二醇二丙烯酸甲酯(EGDMA)0.125～0.875%在有20～45%的水存在下共聚制成,将单体与水相混合,然后放置5分钟
The use of poly (2-hydroxyethyl methacrylate) [Poly (HEMA)] gels has been extensively investigated in drug release controlled polymer implants. The gel is generally polymerized in the presence of water as free radical polymerization of 2-hydroxyethylmethacrylate (HEMA), a monomeric starting material. There are several ways to free radical polymerization: (1) chemical catalysis; (2) UV irradiation in the presence of light-sensitive chemicals; and (3) ionizing radiation. The first two disadvantages are the need to remove the chemicals from the gel or else the biocompatibility with the biological tissues; another disadvantage is that the chemicals may interact with the polymeric bonds to change the network structure of the gel The swelling properties of the gel. This article compares the swelling properties of polymers prepared by γ-ray irradiation and chemical methods. Gel Preparation: Monomeric HEMA and cross-linking agent ethylene glycol methyl acrylate (EGDMA) 0.125 ~ 0.875% in the presence of 20 to 45% water copolymer, the monomer is mixed with the water phase, and then placed 5 minutes