论文部分内容阅读
目的 :探讨内皮素 1 (endothelin 1 ,ET 1 )与蛛网膜下腔出血 (subarachnoidhem orrhage,SAH)后缺血性脑损害的关系和银杏叶制剂 (ginkgobilobaextract,GBE)的防治作用。方法 :应用非开颅大鼠模型 ,对SAH组和GBE组测量基底动脉 (basilarartery ,BA)管径并观察2 4h内微区脑血流量 (regionalcerebralbloodflow ,rCBF)和颅内血浆ET 1水平动态改变 ,3天后对海马CA1区行病理检查。结果 :SAH后rCBF迅速而持续降低 ,血浆ET 1浓度显著增加 ,BA痉挛 ,海马CA1区神经元明显受损。GBE使上述改变均减轻。结论 :SAH时ET 1增加是导致缺血性脑损害的重要因素 ,GBE通过拮抗ET 1病理性增多而减轻缺血性脑损害。
Objective: To investigate the relationship between endothelin 1 (ET 1) and ischemic brain damage after subarachnoidhemorrhage (SAH) and the preventive and therapeutic effects of ginkgo biloba extract (GBE). Methods: The diameters of basilar artery (BA) in SAH group and GBE group were measured and the dynamic changes of regional cerebral blood flow (rCBF) and intracranial plasma ET 1 level were observed within 24 hours in non-craniotomy rats model. , 3 days after the pathological examination of hippocampal CA1 area. Results: After SAH, rCBF decreased rapidly and rapidly, and plasma ET 1 concentration increased significantly. BA spasm and neurons in hippocampal CA1 region were significantly impaired. GBE made all the above changes. CONCLUSIONS: Increased ET 1 is an important factor leading to ischemic brain damage during SAH. GBE attenuates ischemic brain damage by antagonizing the increased pathology of ET 1.