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非胰岛素依赖型糖尿病(NIDDM)有明显遗传倾向,但由于对其遗传异质性认识不足及缺乏研究手段,半个多世纪来研究进展缓慢,80年代起应用分子生物学技术进行遗传学研究,取得迅速发展。 一、与NIDDM关联的基因:NIDDM群体关联研究仍是主要研究途径,通常以致病候选基因(di-sease candidate genes)为研究对象,十多年来在不同种族中已研究20多个候选基因。80年代主要研究与醣、脂代谢有关的激素、受体、载体基因,
Non-insulin-dependent diabetes mellitus (NIDDM) has obvious genetic predisposition, but due to its lack of understanding of genetic heterogeneity and lack of research methods, research has been slow for more than half a century. Since 1980s, molecular biology techniques have been used to carry out genetics research, Achieved rapid development. 1. Genes Associated with NIDDM: The NIDDM population association study is still the main research approach. Often the di-sease candidate genes are the object of study. More than 20 candidate genes have been studied in different races for more than a decade . The 80’s main research and sugar, lipid metabolism related hormones, receptors, vector genes,