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马利兰治疗慢性粒细胞白血病有25年以上历史。一般每天用量2～6mg,对许多病例仍然无效,只是使骨髓增生低下,Ph~1染色体仍然存在,周围血幼稚细胞和脾肿大常不消失。更危险的是,严重骨髓抑制在某些病例可持续数月。大剂量间断治疗能控制细胞毒性作用和避免蓄积中毒,而且正常骨髓不受Ph~1阳性细胞克隆侵袭.本文报道19例患者,均具有典型Ph~1染色体,有6例曾用其他化疗失败后改用本方案。均是只服马利兰胶囊制剂,初期血小板数高于150×10~9/L者用100mg,低于此数者用50mg,以后根据白细胞恢复情况,隔2周重复用药。缓解者白细胞总数低于10×10~9/L,
Maryland treatment of chronic myeloid leukemia more than 25 years of history. The daily dose of 2 ~ 6mg, for many cases still invalid, only low myeloid hyperplasia, Ph ~ 1 chromosome still exists, peripheral blood naive cells and splenomegaly often disappear. More dangerously, severe myelosuppression can persist for some months in some cases. Intermittent treatment with high dose can control cytotoxicity and avoid accumulation of poisoning, and normal bone marrow is not affected by Ph ~ 1 positive cell clones.In this paper, all 19 patients have typical Ph ~ 1 chromosomes and 6 have failed with other chemotherapy Use this program instead. Are only served Maryland capsule preparations, the initial platelet count above 150 × 10 ~ 9 / L with 100mg, less than those with 50mg, after the recovery of leukocytes, repeated medication every 2 weeks. The total number of patients with leukocyte less than 10 × 10 ~ 9 / L,