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汉坦病毒是啮齿类动物传播的病原体 ,可引起严重的人类疾病。经动物模型和人体测定证实 ,核壳 ( N)蛋白具有高度免疫原性 ,普马拉汉坦病毒 ( PUUV) N蛋白能够保护欧筴抵抗大剂量野生型 PUUV的攻击。作者以欧筴为模型对用酵母表达的 PUUV N蛋白的有效保护作用作了评价。 使用
Hantavirus is a pathogen transmitted by rodents and can cause serious human diseases. Nucleocapsid (N) protein was highly immunogenic by animal models and human tests. PUUV N protein was able to protect the plover against the attack of large doses of wild-type PUUV. The authors used Ouluo as a model to evaluate the potent protective effect of the yeast-expressed PUUV N protein. Use