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据Tere5a医生等报道,12名服用避孕药的病人同时加用法华令(Warfarin)来进行长期抗凝,结果其平均凝血酶元时间比例明显上升,或者为达到同样的凝血酶元时间所需要的抗凝药物的剂量明显减少。例如服用避孕药期间某些凝集因素增加,这样可望出现一个对抗效应。作者认为,药物的相互作用尚有待进一步搞清楚。作者最近研究了凝血酶元复合物的活性发现,投给雌大鼠雌激素-孕酮复合物(lynestrenol5mg和mestranol0.3mg/kg体重)的最低浓度时,大鼠百分之百不孕。仅经过一个动情周期,投给避孕药的大鼠,其正规凝血时间(37.2±0.5秒)明显地比对照组大鼠长(31.0±0.4秒)。经过10个动情周期后,这种差异更显著。作者认为,虽在口服避孕药的妇女中尚未见到
According to Dr. Tere5a et al., 12 contraceptive patients also received long-term anticoagulation with Warfarin resulting in a significant increase in their average prothrombin time, or in order to achieve the same thrombin time The dosage of anticoagulants was significantly reduced. For example, some agglutination factors increased during taking contraceptives, so that an antagonistic effect is expected. The authors believe that the interaction of drugs needs to be further clarified. The authors recently studied the activity of the thromboxane complex and found that rats were one hundred percent infertile when administered to the lowest concentrations of estrogen-progesterone complexes (lynestrenol 5 mg and mestranol 0.3 mg / kg body weight) in female rats. Only one estrous cycle, the contraceptives administered to rats, its normal clotting time (37.2 ± 0.5 seconds) was significantly longer than the control rats (31.0 ± 0.4 seconds). After 10 estrous cycles, this difference is even more pronounced. The authors believe that although not yet seen in women taking oral contraceptives