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自 1996年以来 ,对结、直肠癌采用甲酰四氢叶酸钙 (CF)和 5 -氟脲嘧啶 (5 - Fu)联合化疗 2 3例 ,其中术后辅助化疗 19例 ,治疗性化疗 4例 ,全部存活。 19例为术后辅助化疗 ,属Dnkes A期 2例 ,B期 4例 ,C期 13例 ,治疗性化疗 4例均为 D期病例。化疗采用 CF2 0 0 mg/ d和 5- Fu10 0 mg/ d静脉 12小时缓慢滴注 ,连续 5天为 1疗程 ,每日 1次 ,共 6疗程结束化疗。其中 ,3例直肠高分化腺癌 ,术中从肠系膜下静脉插管仍采用 CF/ 5 - Fu化疗 ,每日静点维持 2 4小时连续7天 ,术后继续完成上述方案 6疗程。结果显示 ,2 3例全部存活 ,治疗组病例有较明显缓解 ,表明CF/ 5 - Fu化疗方案不论术后辅助化疗或治疗性化疗均是安全和有效的。
Since 1996, 23 cases of colorectal cancer have been treated with calcium folinate (CF) and 5-fluorouracil (5-Fu) combined chemotherapy, including 19 cases of postoperative adjuvant chemotherapy and 4 cases of therapeutic chemotherapy. All survive. Nineteen patients received postoperative adjuvant chemotherapy, which included 2 cases of Dunkes A stage, 4 cases of B stage, 13 cases of C stage, and 4 cases of therapeutic chemotherapy. Chemotherapy was performed with intravenous infusion of CF2 0 mg/d and 5-Fu10 0 mg/d for 12 hours, followed by 5 consecutive days for 1 course of treatment, once a day, for a total of 6 courses of chemotherapy. Among them, 3 cases had rectal well-differentiated adenocarcinoma. During the operation, CF/5-Fu chemotherapy was continued from the inferior mesenteric vein to intubate. The static point was maintained for 24 hours per day for 7 days. The above protocol was continued after the operation. The results showed that 23 cases of all survival, the treatment group had more obvious relief, indicating that CF / 5-Fu chemotherapy regardless of postoperative adjuvant chemotherapy or therapeutic chemotherapy are safe and effective.