论文部分内容阅读
目的观察注射型唑来膦酸盐治疗骨质疏松的临床疗效,优化临床治疗效果。方法 114例骨质疏松患者,按随机数字表分为观察组和对照组,各57例。对照组给予钙剂与活性维生素D治疗,观察组在对照组的基础上给予注射型唑来膦酸盐治疗,治疗前后进行腰背部疼痛VAS评分,测定腰椎骨密度及髋部骨密度。结果两组治疗后腰背静息痛、腰背前屈后伸痛、腰背翻身痛VAS评分均较治疗前明显降低(P<0.01),观察组治疗后VAS评分均明显低于对照组(P<0.01)。观察组治疗后腰椎骨密度及髋部骨密度较治疗前明显升高(P<0.01),观察组治疗后腰椎骨密度及髋部骨密度明显高于对照组(P<0.01)。结论注射型唑来膦酸盐具有确切的止痛效果,有效缓解骨质疏松性腰背痛,提高骨密度,但其价格昂贵,临床医师应在药物疗效和经济性上进行合理选择。
Objective To observe the clinical efficacy of injectable zoledronic acid in the treatment of osteoporosis and optimize the clinical effect. Methods 114 cases of osteoporosis patients were divided into observation group and control group according to random number table, each 57 cases. The control group was treated with calcium and active vitamin D. The observation group was treated with injection of zoledronic acid on the basis of the control group. VAS scores of lumbar and back pain were measured before and after treatment. The lumbar spine BMD and hip BMD were measured. Results The VAS score of low back pain, back flexion and back pain and back pain in both groups were significantly lower than those before treatment (P <0.01). The VAS score of the observation group was significantly lower than that of the control group P <0.01). The lumbar BMD and hip BMD in the observation group were significantly higher than those before treatment (P <0.01). The lumbar BMD and hip BMD in the observation group were significantly higher than those in the control group (P <0.01). Conclusion Injection zoledronic acid has the exact analgesic effect, effectively relieving osteoporosis low back pain and increasing bone density, but its price is expensive. Therefore, clinicians should make reasonable choice in the curative effect and economy of medicine.