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目的对卡马西平(CBZ)、托吡酯(TPM)和丙戊酸钠缓释片(VPA)在脑炎继发性癫痫疾病治疗中起到的作用及其负面作用进行分析。方法选取201例脑炎继发性癫痫患者,对其资料进行回顾分析,按用药不同分为VPA(71例)、TPM(61例)、CBZ(69例)三组,而后对其在接受了VPA、TPM及CBZ为期1年的治疗之后的疗效进行比较,从而对药物的负面作用做出评价。结果 CBZ对脑炎继发癫痫的总有效率为72.46%,和VPA的78.87%和TPM 80.33%的差异无统计学意义(P>0.05)。TPM不良反应率明显低于另外两组,差异有统计学意义(P<0.05)。结论在采取单一药物治疗手段时,CBZ在部分发作癫痫上的疗效可观,而TPM和VPA对所有类型的脑炎激发的癫痫均起到不错的疗效,而TPM的负面作用较其余两种更少。
Objective To investigate the role of carbamazepine (CBZ), topiramate (TPM) and sodium valproate sustained-release tablets (VPA) in the treatment of secondary epilepsy with encephalitis and its negative effects. Methods Totally 201 patients with epilepsy secondary to encephalitis were selected and analyzed retrospectively. The data were divided into three groups: VPA (71 cases), TPM (61 cases) and CBZ (69 cases) VPA, TPM and CBZ after a one-year treatment of the efficacy of comparison, in order to evaluate the negative effects of drugs. Results The total effective rate of CBZ to epilepsy with secondary encephalitis was 72.46%, which was not significantly different from that of VPA 78.87% and TPM 80.33% (P> 0.05). Adverse reaction rate of TPM was significantly lower than the other two groups, the difference was statistically significant (P <0.05). Conclusions CBZ has a significant effect on partial seizures while taking single drug therapy, whereas TPM and VPA have a good effect on epilepsy induced by all types of encephalitis, while the negative effect of TPM is less than the other two .