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目的探讨槟榔颗粒促进胃动力的作用机理。方法 40例健康志愿者随机分成槟榔组、盐水对照组、进餐组、槟榔+进餐组、盐水+进餐组,应用多导胃电图记录仪检测健康志愿者胃电图4 h。观察胃体、胃窦不同区域的胃电指数。采用ELISA法检测服用槟榔前、后脑肠肽(BGP)激素水平的变化。结果 (1)与盐水对照组比较,槟榔组服药后15 min~2 h胃体及胃窦部的胃电主功率比显著增强(P<0.05),主功率比的高峰值在口服槟榔后的15~30 min时段内;(2)槟榔+进餐组、盐水+进餐组、进餐组餐后2 h内主功率比均大于1,提示餐后主功率较静息期显著增高。槟榔+进餐组胃体中下部和胃窦部主功率比显著高于盐水+进餐组和进餐组(P<0.05)。盐水+进餐组与进餐组比较主功率比差异无统计学意义(P>0.05)。槟榔+进餐组餐后的主频率在胃体中下部和胃窦部显著增高(P<0.05);正常慢波百分比有增高趋势,不稳定系数有下降趋势。(3)激素水平:在服用槟榔后与空腹静息期比较血浆胃动素(MTL)含量显著增高(P<0.05),促肾上腺皮质激素释放激素(CRH)显著降低(P<0.05);与盐水+进餐组比较,槟榔+进餐组服药后及进餐后MTL显著增高,CRH显著降低(P<0.05)。结论槟榔能够通过增强胃电活动促进胃动力,其作用机理可能是通过BGP激素MTL、CRH介导。
Objective To investigate the mechanism of betel nut granule in promoting gastric motility. Methods Forty healthy volunteers were randomly divided into betel nut group, saline control group, meal group, betel nut + meal group, saline + meal group. Gastrogram of healthy volunteers was detected by multi-electrode GGD recorder for 4 hours. Observed gastric body, gastric antrum of different areas of gastric electrical index. The changes of the hormone levels of BGP before and after betel nut were detected by ELISA. Results (1) Compared with the saline control group, the main power ratio of gastric antrum and gastric antrum increased significantly (P <0.05) 15 minutes to 2 hours after treatment in betel nut group. The peak value of main power ratio was (2) Betel nut + meal group, salt water + meal group, the main power ratio of meal group within 2 hours after meal was more than 1, suggesting that the postprandial main power was significantly higher than the rest period. The ratio of the main power in the lower part of gastric body and the antrum in the areca + meal group was significantly higher than that in the salt + meal group and the meal group (P <0.05). There was no significant difference in main power ratio between saline + meal group and meal group (P> 0.05). The main frequency of betel nut + meal group was significantly higher in the lower part of gastric body and gastric antrum (P <0.05); the percentage of normal slow wave increased and the instability coefficient decreased. (3) Hormone level: The content of MTL increased significantly (P <0.05) and corticotropin-releasing hormone (CRH) decreased significantly after betel nut treatment compared with fasting resting period Saline + meal group, betel nut + meal group after taking the medication and meal MTL was significantly higher, CRH was significantly lower (P <0.05). Conclusion Betel palm can promote gastric motility through enhancing gastric electrical activity. Its mechanism may be mediated by MTL and CRH.