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目的:探讨早期乳腺癌术后辅助化疗及一线治疗局部晚期或转移性乳腺癌应用化疗药物泰索帝联合阿霉素后心电图的影响。方法:被确诊为早期乳腺癌、局部晚期或转移性乳腺癌的75例患者,经静脉滴注泰索帝75 mg/m2,联合表阿霉素90 mg/m2,每3周1次,每个疗程开始前和结束后各观测心电图1次,共动态观察6~8个疗程。结果:75例中心率加快8例(10.67%),肢体导联QRS波低电压10例(13.33%),Q-T时间延长6例(8%),ST段压低11例(14.67%),T波倒置9例(12%),未发生变化31例(41.33%)。结论:化疗药物泰索帝联合阿霉素对心脏有毒性,能够引起心肌不同程度损伤,造成慢性心肌缺血缺氧,从而引起心电图QRS波群及ST-T的异常改变。
Objective: To investigate the effect of postoperative adjuvant chemotherapy and first-line electrocardiogram in patients with locally advanced or metastatic breast cancer treated with Taxotere combined with doxorubicin. METHODS: Seventy-five patients diagnosed with early-stage breast cancer and locally advanced or metastatic breast cancer were treated with either docetaxel 75 mg / m 2 intravenously, epirubicin 90 mg / m 2, once every 3 weeks, A course of treatment before and after the end of each observation ECG 1, a total of 6 to 8 courses of dynamic observation. Results: 75 cases were accelerated in 8 cases (10.67%), QRS wave was lower in 10 cases (13.33%), QT prolonged in 6 cases (8%), ST segment depression was in 11 cases (14.67% Inverted nine cases (12%), no change in 31 cases (41.33%). Conclusion: The combination of docetaxel and doxorubicin, which is toxic to the heart, can cause myocardial injury to some extent, resulting in chronic myocardial ischemia and hypoxia, resulting in the abnormal changes of ECG QRS complex and ST-T.