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用核糖核酸（ＲＮＡ）治疗肝炎肝硬化（慢性活动性肝炎（ＣＡＨ）伴代偿期肝硬化）６０例３个月，与辅酶Ｑ１０治疗３个月的另６０例对照。结果表明，ＲＮＡ改善血清蛋白和降ＡＬＴ的疗效明显优于辅酶Ｑ１０。部分病例于治疗前后测定血清Ⅲ型前胶原肽（ＰⅢＰ）和透明质酸（ＨＡ），ＲＮＡ组治疗后血清ＰⅢＰ和ＨＡ的含量明显下降，而辅酶Ｑ１０组变化不明显。用大鼠作光镜和电镜检查均揭示，ＲＮＡ有减轻肝细胞病变和减少胶原纤维增生的作用。临床观察与实验研究结果一致，说明ＲＮＡ有保护肝细胞和抗纤维化的作用。
Liver cirrhosis (chronic active hepatitis (CAH) with compensated cirrhosis) was treated with ribonucleic acid (RNA) for 60 months for 3 months and another 60 controls for 3 months with coenzyme Q10. The results show that RNA is significantly better than coenzyme Q10 in improving serum protein and decreasing ALT. Serum samples of type Ⅲ procollagen peptide (PⅢP) and hyaluronic acid (HA) were measured in some cases before and after treatment. The levels of PⅢP and HA in RNA group were significantly decreased after treatment, but not in coenzyme Q10 group. Using light microscopy and electron microscopy in rats revealed that RNA had the effect of reducing hepatocellular lesions and reducing the proliferation of collagen fibers. Clinical observations and experimental findings are consistent, indicating that RNA has the role of protecting liver cells and anti-fibrosis.