论文部分内容阅读
５０例肝硬化患者配对分成两组，对照组２５例仅给予利尿剂和血制品处理，治疗组２５例除上述治疗外，作肝内胎肝细胞移植（ＩＦＨＴ）。３个月后治疗组与对照组相比血清球蛋白水平非常显著降低（Ｐ＜０．０１），肝功能Ｃｈｉｌｄ分级级等显著提高（Ｐ＜０．０５）。随访１８个月治疗组较对照组血清白蛋白非常显著提高（Ｐ＜０．０１）而球蛋白明显降低（Ｐ＜０．０１），治疗组２２例生存者中有１８例病情稳定，而对照组１９例生存者中仅５例稳定，另１４例系活动性肝硬化。结果提示ＩＦＨＴ能促进肝硬化患者腹水消退，改善肝功能延长生存时间。
Fifty patients with liver cirrhosis were divided into two groups, while 25 patients in the control group were treated with diuretics and blood products only. In the treatment group, 25 patients underwent intrahepatic fetal liver cell transplantation (IFHT). After 3 months, the levels of serum globulin were significantly decreased (P <0.01) and the grades of Child function were significantly increased in the treatment group and the control group (P <0.05). After 18 months of follow-up, serum albumin was significantly increased (P <0.01) and globulin was significantly lower in the treatment group than in the control group (P <0.01), and 18 of the 22 survivors in the treatment group were in stable condition. Only 5 of 19 survivors were stable, and the other 14 were active cirrhosis. The results suggest that IFHT can promote ascites regression in patients with liver cirrhosis and improve liver function to prolong the survival time.