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Rotor氏综合征(慢性家族性非溶血性黄疸)是一种遗传性疾病,其特征是血中结合胆红质过高,磺溴酞钠(BSP)显著潴留,胆囊显影,肝脏无异常的组织学发现。作者试图从测定Rotor氏综合征对胆红质和某些染料的清除率是否有特征性改变的实验,来进一步阐明本病的特征。本文研究了六例Rotor氏综合征患者,1例女性,5例男性,年龄18-65岁,平均30岁。4例有家族发病史,2例是同胞兄妹,4例患者有慢性黄疸史。作者研究了以上患者的BSP、吲哚花青录(ICG)和结合胆红质的血浆清除率。在禁食12-14小时后进行BSP清除率研究。以每公斤体重注射BSP 5mg在30、45、60、90和120分钟后分别采取血标本。以每公斤体重注射ICG0.5mg后,6例均
Rotor’s syndrome (chronic familial non-hemolytic jaundice) is a hereditary disease characterized by hyperbolic binding of bilirubin in the blood, significant retention of sodium sulfochromate (BSP), gallbladder development, and abnormal liver tissue Learn to discover. The authors attempted to further elucidate the characteristics of this disease by experimentally determining whether Rotor’s syndrome has a characteristic change in the clearance of bilirubin and certain dyes. Six patients with Rotor’s syndrome were studied in this study. One patient and five males, aged 18-65 years, average 30 years. 4 cases had a history of family history, 2 cases were siblings siblings, 4 patients had a history of chronic jaundice. The authors studied plasma clearance of BSP, indocyanine (ICG) and bound bilirubin in these patients. BSP clearance studies were performed 12-14 hours after fasting. BSP 5 mg / kg body weight were taken at 30,45,60,90 and 120 minutes after the blood samples were taken. After injection of ICG0.5mg per kg body weight, 6 cases were