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对9例经常吸烟的男性十二指肠溃疡,进行夜间胃分泌的情况观察。试验连续3天。日间活动照常,下午停止吸烟,晚上6点服抗分泌药,其中5次试验服呋喃硝胺150mg,3次试验服甲氰咪胍400mg,3次试验服吩噻嗪衍生物LM24056。晚上8点插胃管,每小时抽吸胃液,至次晨8点。记录每小时胃液量,并测定标本的pH、氢离子浓度及胃蛋白酶活性。有1晚不予吸烟,另2晚可随意吸烟。4例有1晚既不予服药又不予吸烟。另外观察了10例经常吸烟的健康受试者五肽胃泌素刺激胃分泌的情况。试验连续3天。禁食一夜后,以固定的速度(0.5μg/kg/h)静脉注入五肽胃泌素,经胃管抽胃液,每15分钟1次,连续6次。有2天在滴注五肽胃泌素前1小时服抗分泌药,其中6人服甲氰
Of 9 cases of regular smoking in men with duodenal ulcer, the evening gastric secretion observed. Test for 3 consecutive days. Daytime activities as usual, stop smoking in the afternoon, 6 o’clock in the evening to take anti-secretory drugs, of which five trials serving furanitamide 150mg, three trials of cimetidine 400mg, three trials of phenothiazine derivatives LM24056. Gastronomy at 8 o’clock in the stomach, pumping gastric juice every hour until 8:00 the next morning. Gastric fluid volume was recorded hourly, and the pH, hydrogen ion concentration and pepsin activity of the samples were measured. 1 night without smoking, the other 2 nights are free to smoke. Four patients had neither medication nor smoking for 1 night. In addition, pentagastrin was also stimulated in 10 healthy subjects who regularly smoke to stimulate gastric secretion. Test for 3 consecutive days. After a fasting overnight, pentagastrin was infused intravenously at a fixed rate (0.5 μg / kg / h) and gastric juice was pipetted every 15 minutes for 6 consecutive times. There are 2 days before pentagastrin infusion of antisecretory drugs 1 hour, of which 6 patients with cyanide