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目的分析评价江苏地区女性月经、生殖因素与乳腺癌发病风险的关系。方法采用病例对照研究,对经病理确诊的488例乳腺癌病例和482例对照进行月经、生殖因素与乳腺癌关系的单因素和多因素的logistic回归分析。结果单因素logistic回归分析结果显示,初潮年龄大、活产数多能降低乳腺癌的发病危险性;首胎活产年龄大患乳腺癌的危险性增加,有流产史和无母乳喂养史者患乳腺癌的危险性亦增加。多因素logistic回归分析结果与单因素分析结果较为一致。结论月经、生殖因素在江苏地区女性乳腺癌的发病过程中起重要作用。
Objective To analyze and evaluate the relationship between women’s menstruation and reproductive factors and the risk of breast cancer in Jiangsu Province. Methods A case-control study was conducted to investigate the relationship between menstruation and reproductive factors and breast cancer in 488 cases of breast cancer and 482 cases of pathological diagnosis by single factor and multi-factor logistic regression analysis. Results The results of univariate logistic regression analysis showed that menarche age and live birth number could reduce the risk of breast cancer. The risk of breast cancer was increased with the first live birth, and the history of abortion and breastfeeding without breast feeding The risk of cancer also increases. Multivariate logistic regression analysis and univariate analysis of the results are more consistent. Conclusion Menstruation and reproductive factors play an important role in the pathogenesis of breast cancer in Jiangsu Province.