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目的:了解河南省严重精神障碍患者服药现状并探讨其影响因素。方法:采用多阶段分层随机抽样方法抽取患者，利用自编调查问卷收集患者及监护人基线资料，采用Logistic回归分析其影响因素，采用独立样本n t检验和卡方检验比较基线资料。n 结果:本次调查共收集1 872份有效问卷，依从服药患者961?例（51.34%）。Logistic回归分析显示监护人与患者关系、家庭收入水平、年治疗费用支出等10?个因素影响患者服药依从性，其中监护人与患者关系中，与关系为父母比较，夫妻（n Wald χ2=10.491，n P=0.001）、兄弟姐妹（n Wald χ2=10.472，n P=0.001）等是影响服药的危险性因素，且具有增强趋势；家庭收入水平中相对于收入很好，家庭收入水平较好（n Wald χ2=4.373，n P=0.037）、一般（n Wald χ2=4.189，n P=0.041）等是影响服药的保护性因素，影响水平有减弱趋势；患者年龄为45~59?岁（n Wald χ2=7.060，n P=0.008）、监护人与患者共同生活（n Wald χ2=32.029，n P<0.01）、居住地为城镇（n Wald χ2=21.908，n P<0.01）为影响患者服药的保护性因素。n 结论:河南省严重精神障碍患者服药依从性较差，其影响因素复杂，提供干预措施需综合考虑因素间交互作用。“,”Objective:To understand the current status of drug compliance in patients with serious mental disorder in Henan，and to study its influencing factors.Methods:Using stratified random sampling method. The baseline data of patients were collected by self-designed questionnaires. Logistic regression analysis was conducted to determine associated factors. Independent sample n t-test and chi-square test were performed to compare the baseline data of the two groups.n Results:A total of 1 872 valid questionnaires were collected, and the rate of medication compliance in patients with serious mental disorder was 51.34%(961). Through multivariate logistic regression analysis, we found that 10 variables, such as relation ship, household income level, and year treatment cost were significantly associated with drug compliance. Conjugal（n Wald χ2=10.491, n P=0.001）, and sibling relationship (n Wald χ2=10.472, n P=0.001) were the risk factors for drug compliance, and it has an increased tendency. Regarding household income level, compared with the level of ‘good’, the level of ‘very good’, ‘better than good’ （n Wald χ2=4.373, n P=0.037）, and ‘moderate’ (n Wald χ2=4.189, n P=0.041) were the protective factors for drug compliance, and it has a reducing tendency. In addition, patients′ age (45-59 years)(n Wald χ2=7.060, n P=0.008), living status (living together with caregivers)（n Wald χ2=32.029， n P<0.01）, and residency (urban residents)（n Wald χ2=21.908, n P<0.01） were the protective factors for drug compliance.n Conclusions:The current status of drug compliance in patients with serious mental disorder in Henan was rigorous, and its influence factors are complicated. The interaction between factors should be comprehensively considered before applying interventions.