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目的:比较左氧氟沙星与洛美沙星两种喹诺酮类药物治疗细菌感染性结膜炎的临床疗效及安全性差异。方法:78例细菌性结膜炎患者随机分成观察组和对照组各39例,观察组予乳酸左氧氟沙星滴眼液,对照组予洛美沙星滴眼液,疗程均为7 d。比较两组临床疗效、细菌清除率、药品不良反应发生情况。结果:观察组疗效分布显著优于对照组(P<0.05),两组总有效率比较差异无统计学意义(P>0.05)。两组细菌清除率分别为100%、97.06%,差异无统计学意义(P>0.05)两组均未发生严重药品不良反应。结论:左氧氟沙星滴眼液治疗细菌性结膜炎疗效优于洛美沙星。
Objective: To compare the clinical efficacy and safety of two quinolones of levofloxacin and lomefloxacin in the treatment of bacterial conjunctivitis. Methods: A total of 78 patients with bacterial conjunctivitis were randomly divided into observation group (39 cases) and control group (39 cases). The observation group was given levofloxacin lactate eye drops. The control group was treated with lomefloxacin eye drops for 7 days. The clinical efficacy, bacterial clearance and adverse drug reactions were compared between the two groups. Results: The curative effect of the observation group was significantly better than that of the control group (P <0.05). There was no significant difference in the total effective rate between the two groups (P> 0.05). The bacterial clearance rates of the two groups were 100% and 97.06%, respectively, with no significant difference (P> 0.05). No adverse drug reactions occurred in both groups. Conclusion: Levofloxacin eye drops are superior to lomefloxacin in the treatment of bacterial conjunctivitis.