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目的:比较国产与进口硝苯地平控释片治疗高血压病的降压效果和不良反应。方法:选择原发性高血压病患者100例,随机分为观察组和对照组各50例,观察组给予国产硝苯地平控释片,对照组给予进口硝苯地平控释片。两组开始剂量均为30mg,1次/d;2周降压效果不佳者,从第3周加量至60mg,但最大剂量不超过60mg/d;8周为一疗程。结果:两组服药前及服药后8周24h、白昼和夜间平均收缩压和舒张压显著下降,血压从基线水平下降幅度比较,差异不显著(P>0.05);两组发生不良反应分别为13例(26.0%)和12例(24.0%),均较轻微,无须停药。结论:国产与进口硝苯地平控释片治疗高血压病同样有效,不良反应发生率差异不显著(P>0.05)。
OBJECTIVE: To compare the antihypertensive effects and adverse reactions of domestic and imported nifedipine GITS in the treatment of hypertension. Methods: 100 patients with essential hypertension were randomly divided into observation group and control group, 50 cases in each group. The observation group was given domestic nifedipine controlled release tablets while the control group was given controlled release tablets of nifedipine. Two groups began to dose 30mg, 1 / d; two weeks of antihypertensive ineffective, from the first 3 weeks to 60mg, but the maximum dose does not exceed 60mg / d; 8 weeks for a course of treatment. Results: Mean systolic blood pressure and diastolic blood pressure were significantly decreased in both groups before and 8 weeks after medication, and the difference was not significant (P> 0.05) between the two groups. Adverse reactions were 13 Cases (26.0%) and 12 cases (24.0%), were minor, without stopping. Conclusion: Domestic and imported nifedipine controlled release tablets are equally effective in treating hypertension, with no significant difference in the incidence of adverse reactions (P> 0.05).