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为了总结芦荟多糖(AP)对皮肤放射防护效果,回顾性分析2007-08-01-2008-08-01我院放疗的初治鼻咽癌(NPC)患者185例,用AP油膏2mg/mL作为皮肤放射保护剂,从放疗开始至结束予左颈照射野涂抹防护剂,右颈照射野不涂防护剂(空白)对照观察皮肤放射反应。全部患者鼻咽及颈部照射野采用直线加速器8MV X射线照射,辅以电子线照射颈后三角区。颈预防量DT50Gy/25次,根治量60～64Gy/30～32次。鼻咽68～72Gy/34～36次,5次/周。皮肤反应采用RTOG皮肤急性放射损伤分级标准评级。185例患者全部按计划完成放疗,用药组与对照组出现皮肤Ⅰ级放射反应分别为58.9%和71.4%,Ⅱ级分别为37.8%和25.9%,Ⅲ级分别为3.2%和2.7%,χ2=6.388,P=0.041;用药组与对照组出现皮肤Ⅰ级放射反应中位剂量分别为30和36Gy,Ⅱ级分别为50和54Gy,Ⅲ级分别为58和58Gy,χ2=0.350,P=0.839。初步研究结果提示,临床试用该药剂后Ⅱ级、Ⅲ级皮肤反应较高,提示该制剂对皮肤急性放射损伤无保护效果,须予以剂量或剂型改进。
In order to summarize the radioprotective effect of Aloe polysaccharides (AP) on skin, a retrospective analysis of 185 patients with nasopharyngeal carcinoma (NPC) treated with radiotherapy in our hospital from August 2007 to August 2008 with AP cream 2mg / mL As a skin radioprotective agent, from the start to the end of radiotherapy to the left neck irradiation field smear protective agent, right neck irradiation field without protective agent (blank) control the skin radioactivity. All patients with nasopharyngeal and cervical irradiation field using linear accelerator 8MV X-ray irradiation, supplemented by electron irradiation of the posterior triangular area. The amount of cervical prevention DT50Gy / 25 times, radical dose of 60 ~ 64Gy / 30 ~ 32 times. Nasopharyngeal 68 ~ 72Gy / 34 ~ 36 times, 5 times / week. Skin reactions using RTOG Skin Acute Radiation Injury grading standards. All 185 patients completed the planned radiotherapy. The grade Ⅰ radioactive reaction in the drug group and the control group was 58.9% and 71.4% respectively, with grade Ⅱ being 37.8% and 25.9%, grade Ⅲ being 3.2% and 2.7% respectively, χ2 = 6.388, P = 0.041. The median dose-response of grade Ⅰ radioactivity in the drug-treated group and the control group was 30 and 36 Gy, respectively, with grade II of 50 and 54 Gy, grade III of 58 and 58 Gy, andχ2 = 0.350 and P = 0.839, respectively. Preliminary results suggest that the clinical trial of the drug grade Ⅱ, Ⅲ grade skin reaction is high, suggesting that the preparation of the skin with no protective effect of acute radiation injury, to be dose or dosage form improvement.